ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
The Effects of Conventional and Biological Drugs Used for the Treatment of Rheumatoid Arthritis on Quality of Life and Depression
1 Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, Sivas, Turkey  
Eurasian J Med ; : -
DOI: 10.5152/eurasianjmed.2018.18018
Key Words: Rheumatoid Arthritis, DMARD, Depression, Quality of Life
Abstract

Objectives: The present research aims to investigate the effects of conventional and biological drugs, which are used for the treatment of rheumatoid arthritis (RA), on the patients’ quality of life, depression and anxiety.


Patients and Methods
: A total number of 80 patients with a diagnosis of RA based on American College of Rheumatology/Annual European Congress of Rheumatology (ACR/EULAR) 2010 diagnostic criteria were considered in the present study. Patients were classified into two groups as follows: Patients using conventional disease-modifying agents (csDMARDs) alone (Group 1, n=40) and patients using biological disease-modifying agents (bDMARDs) and csDMARD combination (Group 2, n=40). Demographical data of the patients were collected. Levels of rheumatoid factor (RF) and Anti-Cyclic Citrullinated Peptide (anti-CCP) were measured in both groups. All patients completed Disease Activity Score (DAS28), Health Assessment Questionnaire (HAQ), Short Form-36 (SF-36), Beck Depression Scale (BDS) and Hospital Anxiety Depression Scale (HADS).

Results: There was no significant difference between the two groups of patients regarding their demographical characteristics, autoantibody positivity or DAS scores (p>0.05). HAQ scores, all parameters and summary scores of SF-36, BDS and HADS scores were not significantly different between the two groups (p>0.05).


Conclusion
: Results of the present study showed that csDMARDs and bDMARDs, which required a more invasive administration and were associated with serious side effects, were not superior to each other in terms of their effects on the patients’ quality of life. CsDMARD and bDMARD were also not superior to each other regarding their effects on anxiety and depression among RA patients.


Cite this article as
: Yayikci YI, Karadag A. The Effects of Conventional and Biological Drugs Used for the Treatment of Rheumatoid Arthritis on Quality of Life and Depression. Eurasian J Med 2018; DOI: 10.5152/eurasianjmed.2018.18018

Key Words
Authors
All
Author’s Corner
Survey
AVES | Copyright © 2018 Atatürk University Faculty of Medicine | Latest Update: 20.07.2018