ISSN 1308-8734 | E-ISSN 1308-8742
Review
Association of Adipokines and Insulin, which Have A Role in Obesity, with Colorectal Cancer
1 Department of Nutrition and Dietetics, Gazi University, Ankara, Turkey  
2 Department of Nutrition and Dietetics, Biruni University, İstanbul, Turkey  
Eurasian J Med ; : -
DOI: 10.5152/eurasianjmed.2018.18089
Key Words: colorectal cancer, resistine, insülin, adipokines, adiponectin, obesity
Abstract

 

Obesity related diseases are an important part of public health and it is seen that obesity is related with colorectal cancers. Adipocyte hypertrophy and visceral adipose tissue accumulation can cause adipocitis related diseases and pathogenic adipocyte formation. Adipose tissue has a very important and active role in immune response formation. cytokines/adipokines which are secreted from adipose tissue have an active role in communication between adipocytes and macrophages. Thus, visceral adipocitis is related with low grade chronic sistemic inflammation. Also, adipocytes have an important role in colorectal cancer pathogenesis because of proinflammatory cytokines, growth factors and hormones secretion. Most highlighted cytokines are adiponectine, resistine and ghrelin. Also, insulin like growth factor(IGF-1) increase, insulin resistance, plasma insulin levels, glucose and serum free fatty acids levels increase, glucose intolerance, high body mass index are seen to be related with colorectal cancer pathogenesis. Thus, in this review, we focus on the  relationship between colorectal cancer and adipokines and insülin.

 

Cite this article as: Ozata Uyar G, Sanlier N. Association of Adipokines and Insulin, which Have A Role in Obesity, with Colorectal Cancer. Eurasian J Med 2018; 50: 10.5152/eurasianjmed.2018.18089.

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