ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
The Comparison of The Efficacy and Safety of Original and Biosimilar Filgrastim in Prevention of Chemotherapy-Induced Neutropenia in Children with Cancer
1 Department of Pediatric Oncology, Atatürk University School of Medicine, Erzurum, Turkey  
Eurasian J Med ; : -
DOI: 10.5152/eurasianjmed.2018.18030
Key Words: Filgrastim, biosimilar, children, neutropeni
Abstract

Objective: The duration of chemotherapy-induced neutropenia and associated complications has decreased in adults and children due to the prophylactic use of granulocyte colony-stimulating factors (G-CSFs). Biosimilar G-CSFs can play an important role in reducing treatment costs in daily practice. However, there are some concerns among clinicians regarding the efficacy and safety of new biosimilar products. In this study, we compared the efficacy and safety of original and biosimilar filgrastims for the prophylaxis of chemotherapy-induced neutropenia in children.

 

Materials and methods: Thirty children receiving myelosuppressive chemotherapy were enrolled in this study. Filgrastims (5 μg/kg/day) were administered subcutaneously in Group A (biosimilar, Leucostim®; Dem İlaç) and Group B (original drug, Neupogen®; Roche). Hemoglobin, white blood cell (WBC) count, platelet count, transfusion requirements, duration of hospitalization, and frequency and duration of adverse events including fever, neutropenia, and mucositis, were evaluated following 25 cycles of treatment in both groups.

 

Results: The hemoglobin value, WBC count, and platelet count on days 1, 5, and 10, and the red blood cell and platelet transfusion requirements, frequency, duration, and severity of mucositis, and durations of fever, febrile neutropenia, and hospitalization were similar in both groups. Although the mean WBC counts on days 1 and 5 were lower in Group A, the difference was statistically insignificant. Conclusions: The biosimilar filgrastim, Leucostim, is as effective and safe as the original drug for prophylaxis of chemotherapy-induced neutropenia in children.

 

Cite this article as: Buyukavci M, Keskin Yildirim Z. The Comparison of The Efficacy and Safety of Original and Biosimilar Filgrastim in Prevention of Chemotherapy-Induced Neutropenia in Children with Cancer. Eurasian J Med 2018; 50: 10.5152/eurasianjmed.2018.18030

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