ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model
1 Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Ataturk University, Erzurum, Turkey  
2 Department of Pharmacology, Kafkas University School of Medicine, Kars, Turkey  
3 Department of Internal Medicine, Ataturk University School of Medicine, Erzurum/Turkey  
4 Department of Otorhinolaryngology, Head and Neck Surgery, Erzurum Training and Research Hospital, Erzurum, Turkey  
5 Department of Pathology, Ataturk University School of Medicine, Erzurum, Turkey  
6 Department of Biochemistry, Ataturk University School of Medicine Erzurum, Turkey  
7 Department of Biochemistry, Agri Ibrahim Cecen University School of Pharmacy, Ağrı, Turkey  
8 Department of Histology and Embriology, Ataturk University School of Medicine, Erzurum, Turkey  
Eurasian J Med 2019; 51: 75-79
DOI: 10.5152/eurasianjmed.2019.19025
Key Words: Allergy, desloratadine, misoprostol, rat, rhinitis
Abstract

 

Objective: The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR.

 

Materials and Methods: Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group.

 

Results: Desloratadine administration had significantly lower nasal symptoms than the AR group, but nasal symptoms in the AR+M group were better than those in the AR+D group. The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups.

 

Conclusion: We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of these types of drugs should be tested clinically in patients.

 

Cite this article as: Kaya Z, Yayla M, Bilen A, et al. Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model. Eurasian J Med 2019; 51(1): 75-9.

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