ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
Training Induced Oxidative Stress-Derived DNA and Muscle Damage in Triathletes
1 Centre for Research and Innovation Management, National Defence University of Malaysia, Kuala Lumpur, Malaysia  
2 Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia  
Eurasian J Med ; : -
DOI: 10.5152/eurasianjmed.2019.18106
Key Words: DNA damage; triathlete; endurance training; myoglobin; cardiac troponin I
Abstract

Objectives: Regular moderate intensity exercise has beneficial health effects, while regular strenuous exercise increases production of oxidants that may lead to DNA, skeletal and cardiac muscle damage. Triathletes experience strenuous muscular activity both during competition and training, being at risk of developing these tissue damages. The objective of this study was to estimate DNA, skeletal and cardiac muscle damage using blood biomarkers, 8-hydroxy-2’-deoxyguanosine, myoglobin and cardiac troponin I among young triathletes.

 

Methods: Seven age-matched male and seven female triathletes were recruited for the study. They were on a standardized training regimen and on average competed in at least one endurance event every month for the past 3-4 years. Serum biomarkers were measured using enzyme-linked immunosorbent assay at the start and at end of the racing season.

 

Results: Both male and female triathletes showed a statistically significant increase in 8-hydroxy-2’-deoxyguanosine. A similar pattern of increase was seen with serum myogoblin, which was not statistically significant in both males and females. Cardiac troponin I levels did not show any change in both sexes.

 

Conclusions: Our study shows that there could be an increased evidence of DNA damage among triathletes. However similar effects were not observed with skeletal and cardiac muscle biomarkers.

 

You may cite this article as: Zainudin H, Caszo BA, Knight VF, Gnanou JV. Training Induced Oxidative Stress-Derived DNA and Muscle Damage in Triathletes. Eurasian J Med 2019; DOI: 10.5152/eurasianjmed.2019.18106

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