Abstract

This research presents the effect of Lidocaine after experimental hemispheral cerebral ischemia, induce by unilateral carotid artery ligation. Right common carotid artery ligation was applied to 20 mouses after being anesthetized by halothan inhalation. 10 mouses received lidocaine intravenously (5mg/kg), in the study group 30 minutes prior to carotid artery ligation, while the control group was receiving on equivalent volume of 5% dextrose, 0.2% saline. 20 mouses (10 lidocaine treated and 10 control) were sacrified after 6 hours of common carotid artery ligation and the brains were removed. Neurological changes were also observed within the duration of ischemia. After fixation, the brains were sectioned coronally into 3mm slices and the most extensive ischemic area for each subject was selected following histological assesment of the whole slices. After ligh microscopic evaluation of neural alternations in both lidocaine treated and control groups, we concluded that lidocaine has a significant protective effect in experimental ischemia.