The Eurasian Journal of Medicine
Original Article

Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis

Eurasian J Med 2017; 49: 161-166
DOI: 10.5152/eurasianjmed.2017.17181
Read: 1148 Downloads: 597 Published: 03 September 2019

Abstract

Objective: While the incidence of sarcoidosis peaks between 20 and 39 years, it is comparatively low in elderly subjects. We sought to determine whether there are age-dependent differences in the demographic and laboratory characteristics of patients with sarcoidosis.

 

Materials and Methods: We retrospectively collected information from our database using the International Classification of Disease (ICD) diagnostic code D86 between 2008 and 2014. Patients were divided into three groups: 20–39 years old (Group 1), 40–59 years old (Group 2), and 60–80 years old (Group 3).

 

Results: A total of 3988 patients with code of D86 were included in the study. After the exclusion of non-eligible patients, the number of cases in Groups 1, 2, and 3 were 276, 641, and 352, respectively. The groups were compared according to demographic characteristics, ICD diagnostic codes, and laboratory parameters. The ratio of female patients was significantly higher in Group 3 than in Groups 1 and 2 (p=0.000). There was no difference in diagnostic codes of the ICD subgroups between groups (p=0.19). While the level of blood-urea nitrogen was significantly higher in Group 3 patients than in other groups (p=0.000), serum angiotensin-converting enzyme (ACE) values were found to be significantly low in Group 3 (p=0.010). The mean ACE values did not differ between females and males (50.8±39.3 and 59.1±45.5 mg/dL, respectively) (p=0.18).

 

Conclusion: The majority of patients with sarcoidosis were female in all age groups and pulmonary sarcoidosis was the most common presentation of the disease. Elderly patients (≥60 years) with sarcoidosis had lower serum ACE levels than younger patients.

 

Cite this article as: Durmus Kocak N, Gungor S, Aka Akturk U, et al. Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis. Eurasian J Med 2017; 49: 161-6.

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