Association Between Mean Platelet Volume and Other Inflammatory Markers in Patients with Influenza A (H1N1)

Background: Influenza is a viral infection affecting all age groups, with high transmissibility and the potential to cause epidemics and pandemics. Accurate and early prognosis prediction is essential for effective disease management and outbreak control. The objective of the present research was to assess the significance of mean platelet volume (MPV) and its relationship with inflammatory markers, particularly C-reactive protein (CRP), in predicting the prognosis of Influenza A (H1N1) infection.

Methods: A retrospective analysis was conducted on 133 hospitalized patients who presented with respira tory symptoms and tested positive for H1N1 via nasopharyngeal swab. Data on MPV and CRP levels were collected at admission. The presence of comorbidities and clinical outcomes, including mortality, were also recorded. The relationship between MPV, CRP, and patient outcomes was statistically evaluated.

Results: Comorbid conditions were found in 66.2% of the patients. Among the 31 patients who died (23.3%), 77.4% had comorbidities. Mortality was significantly higher in those with comorbidities (27.3%) than those without (15.5%). Compared with the healthy control group, patients exhibited a markedly lower MPV and higher CRP levels (both P < .005). Intensive care unit (ICU) patients had higher CRP levels than non-ICU patients (P < .005), but MPV did not differ significantly (P = .638). Higher CRP was associated with mortality (P < .005), whereas MPV showed no significant association (P = .086).

Conclusion: H1N1 infection has the potential to cause severe and fatal outcomes, particularly in elderly patients with comorbidities. Elevated CRP at admission may serve as a valuable prognostic marker. Although MPV may contribute diagnostically, its prognostic utility appears limited compared to CRP.

Cite this article as: Tüzün Z, Saler T, Tüzün K, Çelik U, Avci BŞ. Association between mean platelet volume and other inflammatory markers in patients with influenza A (H1N1). Eurasian J Med. 2025, 57(4), 0972, doi:10.5152/eurasianjmed.2025.25972.