The Eurasian Journal of Medicine
Original Article

Comparison of functional capacity and symptoms of copd patients with and without pulmonary hypertension

Eurasian J Med 1; 1: 0-0
DOI: 10.5152/eurasianjmed.2019.18391
Read: 56 Downloads: 11 Published: 03 September 2019


Objective: Pulmonary hypertension (PH) is a common complication of COPD, which is associated with a decrease in survival rate in COPD patients. Our aim was to investigate whether PH impairs functional capacity and symptoms in COPD patients. In addition, we aimed to evaluate the correlation between functional capacity and symptoms score in COPD patients.


Material and Methods: This prospective cross-sectional study enrolled 64 patients with moderate to severe COPD prospectively. All patients underwent pulmonary function test, echocardiography, six-minute walk test, and cardiopulmonary exercise testing (CPET). We applied the modified Medical Research Council (mMRC) dyspnea scale and COPD Assessment Test (CAT) to all patients. Mean pulmonary artery pressure (mPAP) >30 mmHg with echocardiography was considered as PH. They were grouped according to the presence of PH as COPD-PH(n:30) and COPD-nonPH (n:34).


Results: Hospitalization history was higher in COPD-PH group than COPD-nonPH group (p=0.006). Six-minute walk test results were lower in the COPD-PH group compared to the COPD-nonPH group(325±61 m vs. 354±46 m, respectively, p=0.025). In the COPD-PH group, maximum oxygen consumption (VO2max) was lower, but the difference did not reach statistical significance (p=0.118). Although maximum load and minute ventilation were lower in the COPD-PH group, the end-tidal pressure of CO2 (PETCO2) was higher (p=0.033, p=0.036, and p=0.009, respectively). However, the CAT score and mMRC were similar between groups (p=0.405 and p=0.238, respectively).


Conclusions: Elevated PAP in COPD patients limits exercise capacity. Using CPET in the functional evaluation of COPD patients may be beneficial in the early detection of PH.


You may cite this article as: Kalkan F, Yilmazel Ucar E, Kalkan K, Araz Ö. Comparison of functional capacity and symptoms of copd patients with and without pulmonary hypertension. Eurasian J Med 2019; DOI: 10.5152/eurasianjmed.2019.18391.

ISSN1308-8734 EISSN 1308-8742