The Eurasian Journal of Medicine
Original Article

Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy

Eurasian J Med 2019; 51: 70-74
DOI: 10.5152/eurasianjmed.2019.18299
Read: 6748 Downloads: 570 Published: 03 September 2019



Objective: This study aims to compare the effects of different inhalation anesthetics on oxidative status by measuring thiol-disulfide homeostasis in laparoscopic cholecystectomy surgeries. The effect of inhaler agents on thiol-disulfide homeostasis that shows the oxidative status in laparoscopic cholecystectomy is unknown.


Materials and Methods: In this study, 71 patients planned to undergo laparoscopic cholecystectomy under general anesthesia were included. They were divided into two groups: desflurane (group D, n: 35) and sevoflurane (group S, n: 36). Blood samples were taken before induction (T1), at 30th minute of insufflation (T2) (30th min of ischemia), and at 30th min postdeflation (T3) (30th min of reperfusion). The native thiols (–SH) and total thiols (–SH+ –SS) were determined. The amounts of disulfide (–SS), disulfide/native thiol percent ratios (–SS/–SH), disulfide/total thiol percent ratios (–SS/–SH+–SS), and native thiol/total thiol percent ratios (–SH/–SH+ –SS) were calculated.


Results: In the sevoflurane group, preoperative values and intraoperative 30th-minute SS–SH ratio were significantly reduced (p=0.017). In the desflurane group, intraoperative native thiol values and postdeflation levels significantly decreased compared to those in the preoperative values (p<0.001).


Conclusion: We think that the usage of sevoflurane was more protective in terms of the oxidative damage occurring during laparoscopic surgery.


Cite this article as: Dumanlı Ozcan AT, Doger C, Ozturk L, et al. Comparison of the effects of sevoflurane and desflurane on thiol-disulfide homeostasis in patients undergoing laparoscopic cholecystectomy. Eurasian J Med 2019; 51(1): 70-4.

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