The Eurasian Journal of Medicine
Original Article

Destructive Effects of Acidic Blood on the Intestines: Experimental Study

1.

Department of Pediatric Surgery, Ataturk University School of Medicine, Erzurum, Turkey

2.

Department of General Surgery, Division of Breast and Endocrine Surgery, Atatürk University School of Medicine, Erzurum, Turkey

3.

Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey

4.

Deparment of Pathology, Atatürk University,MedicalFaculty, Erzurum,TURKEY

5.

Department of Neurosurgery, Ataturk University School of Medicine, Erzurum, Turkey

6.

Department of Radiology, Ataturk University School of Medicine, Erzurum, Turkey

Eurasian J Med 2021; 53: 22-27
DOI: 10.5152/eurasianjmed.2021.20035
Read: 154 Downloads: 86 Published: 22 February 2021

Objective: This study aimed to investigate the destructive effects of acidic blood on the intestinal structures, which has been reported as the most hazardous biochemical result of vagosympathetic autonomic imbalances in intensive care unit patients with subarachnoid hemorrhage (SAH).

Materials and Methods: In total, 27 hybrid rabbits were used; 5 rabbits were used as a control group, 7 as the SHAM group into whom 1 cc saline was injected into the cisterna magna, and the remaining 15 were used as the study group. These animals received 1 cc of autologous arterial blood injection into the cisterna magna to create the SAH group. Blood pH values were recorded before, during, and after the experimental procedures. Computed tomography was performed to examine the intestinal morphology. Normal and degenerated epithelial cell densities of the intestine were estimated by stereological methods. The relationship between pH values and intestinal tissue changes was analyzed statistically using the Mann–Whitney U test. 

Results: The mean blood pH values were 7.364±0.042 in the control group, 7.326±0.059 in the SHAM group, and 7.23±0.021 in the study group. Intestinal epithelial cell injury, desquamation of villus, and cell loss were observed. It is observed that the number of degenerated epithelial cells, fragmented villi numbers, and vacuoles significantly increased in the study group (p<0.05). 

Conclusion: Acidotic intestinal injury secondary to blood pH changes following SAH may be considered as a generalized and dangerous complication with their multiorgan insuficiency effect.

Cite this article as: Caglar O, Karadeniz E, Firinci B, et al. Destructive Effects of Acidic Blood on the Intestines: Experimental Study. Eurasian J Med 2021; 53(1): 22-7.

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