The Eurasian Journal of Medicine

Exploring Horizons in the Treatment of Vasoplegia in Shock Syndromes


Marília Medical School, Av. Monte Carmelo, Marília, Brazil


Department of Surgery & Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

Eurasian J Med 2022; 54: Supplement S168-S171
DOI: 10.5152/eurasianjmed.2022.22094
Read: 748 Downloads: 379 Published: 01 December 2022

Vasoplegic endothelial dysfunction stands out as one of the most prominent shock syndromes in the intensive care unit, and despite continual therapeutic advances, it is still associated with poor prognosis in critical cases. This scenario is compatible with a significant inflammatory disturbance, with a propensity for increased vascular permeability and deterioration of endothelial response to modulators: a microcirculation disaster. The hemodynamic support's backbone is based primarily on fluid replacement and the use of vasopressor and inotropic agents in nonresponsive patients, aiming to establish a mean arterial pressure of at least 65 mmHg and therefore promote adequate tissue reperfusion. The present study’s primary target is to discuss the combination of 3 concepts as a useful strategy for improving results against the high rates of mortality in critically ill patients. These 3 concepts are (1) the use of “broad-spectrum vasopressors,” (2) vasopressorsparing strategy, and (3) microcirculation protection.

Cite this article as: Oliveira dos Santos Soares R, Roberto Barbosa Evora P. Exploring horizons in the treatment of vasoplegia in shock syndromes. Eurasian J Med., 2022;54(Suppl. 1):S168-S171.

EISSN 1308-8742