The Eurasian Journal of Medicine
Review

Genetic Forms of Calciopenic Rickets

1.

Department of Pediatrics, Regional Training and Research Hospital, Erzurum, Turkey

2.

Department of Medical Genetics, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey

3.

Department of Pediatric Endocrinology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey

Eurasian J Med 2022; 54: Supplement S159-S163
DOI: 10.5152/eurasianjmed.2022.22322
Read: 25 Downloads: 8 Published: 11 January 2023

Rickets is a disease involving calcium and phosphate balance disturbances in the pediatric population. A series of hereditary disorders known as vitamin D-dependent rickets are defined as early-onset rickets resulting from either an insufficient response to active vitamin D or an inability to maintain adequate levels of the active forms of vitamin D. According to the age at onset and the pathophysiology of the disease, various clinical signs including growth failure, limb bowing, and joint enlargement may be present. Vitamin D-dependent rickets type 1A, type 1B, type 2A, type 2B, and type 3 are classified as genetic forms. Further studies are crucial for the development of targeted therapies and future mutation-specific therapies.

Cite this article as: Donmez AS, Turkyilmaz A, Cayir A. Genetic forms of calciopenic rickets. Eurasian J Med., 2022;54(Suppl. 1):S159-S163.

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