The Eurasian Journal of Medicine
Original Article

High Fetuin-A Levels in Children with Celiac Disease


Departman of Medical Biochemistry, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey


Departman of Nutrition and Dietetics, Faculty of Healthy Sciences, Ataturk University, Turkey


Department of Pediatric Gastroenterology, Hepatology and Nutrition, Marmara University School of Medicine, Istanbul, Turkey


Departman of Medical Biochemistry, Faculty of Medicine, Amasya University, Turkey


Department of Pediatric Endocrinology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey

Eurasian J Med 2022; 54: 186-190
DOI: 10.5152/eurasianjmed.2022.21293
Read: 460 Downloads: 168 Published: 01 June 2022

Objective: Fetuin-A is a multifunctional non-collagen protein that plays a role in bone mineralization. Celiac disease is a chronic inflammatory disorder of the small intestine due to exposure to gluten. In this research, it was aimed to investigate levels of Fetuin-A and its relationship with bone mineral density in children with celiac disease.

Materials and Methods: The study was conducted on 59 children with celiac and 29 healthy children. The celiac disease group was composed of three groups, newly diagnosed, gluten-free diet compliant and, non- gluten- free diet compliant patients. Serum Fetuin-A concentrations were measured by an enzyme-linked immuno- sorbent assay kit. Measurement of bone mineral density was performed a dual-energy x-ray absorptiometry.

Results: Serum Fetuin-A levels were 136.85 ± 38.09 μg/L and 112.95 ± 44.39 μg/L in the celiac disease and healthy control groups, respectively. There was a statistically significant difference between groups in levels of serum Fetuin-A (P < .05). A significant positive correlation was observed between serum Fetuin-A and bone mineral density Z-score in the celiac patients.

Conclusion: Increased Fetuin-A levels and positive correlation between Fetuin-A and bone mineral density in children with celiac disease suggest that Fetuin-A may be a biomarker for celiac disease.

Cite this article as: Kurt N, Betul Ozgeris F, Volkan B, Ali Gul M, Cayir A. High fetuin-A levels in children with celiac disease. Eurasian J Med 2022;54(2):186-190.

EISSN 1308-8742