Abstract

Objective: In this study we aimed to evaluate alterations occurred in serum erythropoietin (EPO) levels in isoproterenol (ISO) induced myocardial infarction (MI) model of rats and also aimed to determine effects of amiodarone (AMI) at different doses on EPO levels in rats with and without MI.

Materials and Methods: In this study we induced both acute and chronic MI models in rats. For this purpose 180 mg/kg dose of ISO was used. Treatment groups received 30 and 100 mg/kg doses of AMI. At the end of experiment EPO levels were determined in blood samples collected form rats. Results were compared with that of acute MI, chronic MI and intact healthy rat groups.

Results: Our results demonstrated that serum EPO levels did not changed in acute and chronic MI models when compared to health intact rats. Also AMI application at different doses could not change serum EPO levels in any group.

Conclusion: In this study it has been determined that no significant difference occurs in EPO levels in both acute and chronic MI model which induced by ISO application. Also giving low and high doses of AMI as pharmacological treatment did not alter EPO levels significantly in rats with or without MI. However future detailed studies on different MI models are required to strengthen our result.