The Eurasian Journal of Medicine
Original Article
Is Ebselen A Therapeutic Target in Fracture Healing?

Is Ebselen A Therapeutic Target in Fracture Healing?

1.

Department of Orthophedics and Traumatology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey

2.

Department of Pharmacology, Ataturk University School of Medicine, Erzurum, Turkey

3.

Department of Orthophedics and Traumatology, Ataturk University School of Medicine, Erzurum, Turkey

4.

Department of Histology and Embryology, Ataturk University, School of Medicine, Erzurum, Turkey

Eurasian J Med 2020; 52: 171-175
DOI: 10.5152/eurasianjmed.2020.18443
Read: 186 Downloads: 134 Published: 05 June 2020

Objective: We investigated the effect of ebselen on fracture healing in an experimental fracture model.

Materials and Methods: We divided rats into two groups, 6 rats in each: the experimental femur fracture control group and the ebselen treatment group with an experimental femur fracture. In the experimental femur fracture control group, we created only experimental femur fracture. In the ebselen treatment group, we administered ebselen treatment with creating an experimental femur fracture. We administered ebselen intraperitoneally at 5 mg/kg once daily for 1 month after the 1st day of experimental femur fracture in the ebselen treatment group. We evaluated the recovery status of fractured femurs at the end of 1st month with radiographic, histopathological, and immunohistochemical methods.

Results: According to the radiographic fracture healing scores, ebselen treatment increased the extent of new bone formation and fracture cartilage callus significantly compared to the control group. According to the histopathological recovery scores, ebselen treatment significantly improved healing scores compared to the control group. Ebselen treatment increased the expression scores of bone healing markers in the ebselen treatment group, such as vascular endothelial growth factor and osteocalcin, compared to the control group.

Conclusion: We demonstrated that ebselen treatment increases the formation of new bone in the femur in an experimentally created femoral fracture model. Ebselen has been shown to improve the bone fracture healing in a radiological and histopathological manner, and more detailed studies are needed.

Cite this article as: Kose A, Kose D, Halici Z, et al. Is Ebselen a Therapeutic Target in Fracture Healing. Eurasian J Med 2020; 52(2): 171-5.

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