Paraoxonase Activity and Phenotype Distribution in Patients with Chronic Obstructive Pulmonary Disease

Objective: Paraoxonase1 (PON1) and arylesterase (ARE) enzyme have an important role in prevention of oxidative stress which was related to the pathogenesis of chronic obstructive pulmonary disease (COPD). PON1 level vary widely among individuals and ethnic groups, which is in part correlated with polymorphisms.

Materials and Methods: We investigated paraoxonase 1 and arylesterase activity and phenotype distribution in COPD patients and healthy individuals. Sixty six COPD patients and fifty nine control subjects were involved in the study. Serum PON1 and ARE activities were detected by spectrophotometric method. The ratio of salt-induced PON1 to arylesterase activity was used for determination of phenotypes as QQ, QR and RR.

Results: COPD patients exhibited higher PON1 activity (199.1 vs 129.2, p= 0.002) but lower ARE activity compared to control (21.3 vs 33.5, p= 0.021). There was a significant difference between COPD and control group with respect to PON1 phenotype characteristics. RR phenotypic distribution was more common in the COPD group than in control (60.6% [95% CI: 48.8-72.3] versus 22.0 % [95%CI: 12.0-31.9], p= 0.001). We also found that smoking (95.0% CI: 0.001-0.036, p< 0.001), and RR phenotype (95.0% CI: 0.006-0.59, p= 0.016) are independent determinants in COPD.

Conclusion: We found that RR phenotype was more common in COPD pateints compared to control. Smoking and RR phenotype may be defined as independent factors associated with COPD.

Cite this article as: Sarioglu N, Bilen C, Cevik C, et al. Paraoxonase Activity and Phenotype Distribution in Patients with Chronic Obstructive Pulmonary Disease. Eurasian J Med 2020; 52(2): 161-5.