The Eurasian Journal of Medicine
Original Article

Retinal Nerve Fiber Layer Thickness in Prediabetic Patients


Department of Internal Medicine, University of Ataturk School of Medicine, Erzurum, Turkey


Department of Ophtalmology, University of Ataturk School of Medicine, Erzurum, Turkey


Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Ataturk School of Medicine, Erzurum, Turkey

Eurasian J Med 2022; 54: 8-11
DOI: 10.5152/eurasianjmed.2022.20420
Read: 1173 Downloads: 567 Published: 01 February 2022

Objective: Diabetic retinopathy is a leading cause of blindness. Diabetic retinopathy is not only seen in diabetic patients with the clinical diagnosis but also in prediabetic patients. The aim of this study is to evaluate the RNFL thickness in prediabetic patients.

Materials and Methods: In this study, 50 prediabetic patients and 50 healthy individuals were included. RNFL measurements were performed with SD-OCT in patients with prediabetes and healthy controls.

Results: The mean RNFL thickness for the prediabetic group was 94.7 ± 6.3 μm, inferior quadrant (120 ± 11.6), superior quadrant (112.3 ± 14.13), nasal quadrant (71 ± 12.9), and temporal quadrant (65.3 ± 9.2 μm). The mean RNFL thickness for the control group was 98.9 ± 7.5 μm, inferior quadrant (128 ± 14.7), superior quadrant (116.3 ± 15.12), nasal quadrant (77 ± 15.8), and temporal quadrant (71.2 ± 10.3 μm). Variance analysis demonstrated that the RNFL thickness difference between the groups was significant in all quadrants (P < .001).

Conclusion: RNLF thinning can be seen in prediabetic patients before obvious vascular damage has occurred, and it may present in prediabetic patients not only in the temporal quadrant but also in all quadrants. The early retinal neural changes shown in this study in prediabetic patients may help to better understand the process leading to diabetic overt retinopathy.

Cite this article as: Bilen A, Ates O, Ondas O, Bilen H, Capoglu I. Retinal nerve fiber layer thickness in prediabetic patients. Eurasian J Med 2022;54(1):8-11.

EISSN 1308-8742