The Eurasian Journal of Medicine
Review

The Role of Alpha-2 Adrenergic Receptors in Anti-ulcer Activity

Eurasian J Med 2012; 44: 43-45
DOI: 10.5152/eajm.2012.09
Read: 1376 Downloads: 1063 Published: 03 September 2019

Abstract

 

Although peptic ulcer disease has long been recognized, the proposed mechanisms of its etiopathogenesis change every year. This review shows that gastric ulcers have a significant relationship with alpha-2 adrenergic receptors. The aggravating factors of gastric ulcer formation have been reported to act by blocking alpha-2 adrenergic receptors, whereas drugs possessing anti-ulcer activity have been shown to ensure gastric protection by stimulating the alpha-2 adrenergic receptors. The data derived from the literature indicate the likelihood that any drug or substance selectively stimulating the alpha-2 adrenergic receptors may possess anti-ulcer activity. 

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EISSN 1308-8742