ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
Developing an online portal for determining the genomic signature of Archaic DNA that are associated to modern human genetic diseases: A meta-analysis study
1 Department of Biomedical Engineering, Near East University Faculty of Engineering, Near East Boulevard, Nicosia, 99138, Cyprus  
2 Department of Medical Biology, Near East University Faculty of Medicine Near East Boulevard, Nicosia, 99138, Cyprus  
Eurasian J Med ; : -
DOI: 10.5152/eurasianjmed.2019.18424
Abstract

Objectives: Mutations or introgression can cause and rise adaptive allele up which some can be beneficial alleles. Archaic humans lived more than 200,000 years in Europe and Western Asia. They were adapted to these environments and local pathogens of these environments. It is therefore thinkable that modern humans obtained a significant immune advantage from the archaic alleles.

 

Materials and methods: Firstly, the data collected by meta-analysis from previously identified the genetic disease caused alleles that are intogressed from Archaics. Secondly, the in-silico model portal (http://www.archaics2phenotype.xxx.edu.tr) was designed to trace the history of the Neanderthal allele, however also it shows current distribution of the genotypes of those selected alleles within different populations and correlates with the persons’ phenotype.

 

Results: Our developed model provides the better understanding for the origin of the genetic diseases or traits that are association with Neanderthal genome.

 

Conclusion: This precise medicine model will help the individuals and their belonged populations to receive the best treatment. Finally, it will be the strong answer of the question of why there are differences in disease phenotypes in modern humans.

 

You may cite this article as: Senturk N, Cerkez Ergoren M. Developing an online portal for determining the genomic signature of Archaic DNA that are associated to modern human genetic diseases: A meta-analysis study. Eurasian J Med 2019; 10.5152/eurasianjmed.2019.18424.

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