ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
Is Ebselen A Therapeutic Target in Fracture Healing?
Kose A 1 ,  
Kose D 2 ,  
Halici Z 3 ,  
Aydin A 4 ,  
Ezirmik M 5 ,  
Karsan O 5 ,  
1 Orthopedics surgeon, Department of Orthophedics and Traumatology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey  
2 Medical Doctor, Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey  
3 Medical Doctor, Professor, Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey  
4 Orthopedics surgeon, Associate professor, Department of Orthophedics and Traumatology, Faculty of Medicine, Ataturk University, Erzurum, Turkey  
5 Orthopedics surgeon, Professor, Department of Orthophedics and Traumatology, Faculty of Medicine, Ataturk University, Erzurum, Turkey  
6 PhD student, Department of Histology and Embryology, Faculty of Medicine, Ataturk University, Erzurum, Turkey  
Eurasian J Med ; : -
DOI: 10.5152/eurasianjmed.2019.18443
Key Words: ebselen, bone, fracture healing, vascular endothelial growth factor, osteocalcin
Abstract

Objective: We investigated the effect of ebselen on fracture healing in an experimental fracture model.

 

Material and Methods: We divided rats into two groups of 6 rats in each group: experimental femur fracture control group and ebselen treatment group with experimental femur fracture. In experimental femur fracture control group, we created only experimental femur fractures. In experimental femur fracture and in the ebselen treatment group, we administered ebselen treatment by creating experimental femur fracture. We administered Ebselen intraperitoneally at 5 mg / kg once daily for 1 month after the first day of experimental femur fracture in the Ebselen treatment group. We evaluated the recovery status of fractured femurs at the end of 1 month with radiographic, histopathological and immunohistochemical methods.

 

Results: According to the radiographic fracture healing scores, ebselen treatment increased the percentage of new bone formation and fracture cartilage callus significantly compared to the control group. According to the histopathological recovery scores, ebselen treatment significantly improved healing scores compared to the control group. Ebselen treatment increased the expression scores of bone healing markers such as vascular endothelial growth factor and osteocalcin compared to the control group in the ebselen treatment group. Discussion: We demonstrated that ebselen treatment increases the formation of new bone in femur in experimentally created femoral fracture model.

 

Conclusion: Ebselen has been shown to improve bone fracture healing in a radiological and histopathological manner and more detailed studies are needed.

 

You may cite this article as: Kose A, Kose D, Halici Z, et al. Is Ebselen A Therapeutic Target in Fracture Healing? Eurasian J Med 2019; 10.5152/eurasianjmed.2019.18443.

Key Words
Authors
All
Author’s Corner
Survey
AVES | Copyright © 2019 Atatürk University Faculty of Medicine | Latest Update: 19.06.2019