ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
The Relationship Of Suv Value In Pet-Ct With Tumor Differentiation And Tumor Markers In Gastric Cancer
1 Department of Nuclear medicine, medicine Faculty, Ataturk University, Erzurum, Turkey Central Campus-Yakutiye-ERZURUM/TURKEY  
2 Department of Nuclear medicine, Private Yücelen Hospital, Muğla, Turkey [email protected]  
Eurasian J Med ; : -
DOI: 10.5152/eurasianjmed.2019.19016
Key Words: Gastric cancer, FDG-PET/CT, initial staging, SUVmax, tumor markers
Abstract

Purpose: In this study, we aimed to investigate the relationship between the use of FDG-PET/CT, SUVmax value of tumor and tumor differentiation and tumor markers in initial staging of patients with gastric cancer.

 

Materials and Methods: The study included 50 patients (14 F, 36 M, mean age; 63 ± 11 years, age range; 31-80 years) who have undergone initial staging with FDG-PET/CT after the diagnosis of gastric cancer with endoscopic biopsy between January and June 2013. Serum AFP, CA 19-9, CEA and CRP levels were measured in patients prior to imaging. PET/CT images were evaluated for primary tumor, locoregional spread and distant organ metastases, and classified by TNM staging. Semiquantitative data were collected by SUVmax measurement in pathological regions of involvement. Data were analyzed statistically.

 

Findings: FDG-PET/CT showed primary gastric cancer with a sensitivity of 87%. Imaging findings were normal in three patients (1/3; mucinous adenocarcinoma, 2/3; signet-ring cell adenocarcinoma). With FDG-PET/CT, 3/50 patients were classified into Stage 1B, 3/50 patients into Stage 2, 5/50 patients into Stage 3A, 5/50 patients into Stage 3B, 5/50 patients into 3C and 29/50 patients into Stage 4. The mean SUVmax; was calculated as 11.35 ± 4.3 (poorly differentiated adenocarcinoma; 5.4 ± 1.7, moderately differentiated adenocarcinoma; 10.3 ± 4.8) for the primary tumor and 14.9 ± 6.3 for tumor metastasis. There was a positive correlation between the measured SUVmax and stage and the grade of primary tumor (p <0.05). While the relationship between SUVmax and serum AFP and CRP levels was statistically significant (p <0.05), the relationship between it and serum CA 19.9 and CEA levels was not statistically significant (p> 0.05).

 

Result: In our study, the SUVmax value of primary tumor was found to be connected with the degree of differentiation of primary tumor and biochemical tumor markers CRP and AFP. The fact that SUVmax value of the primary tumor is high is important in terms of giving clues about the presence of the said factors affecting the prognosis of the disease.

 

You may cite this article as: Maman A, Sahin A, Ayan AK. The Relationship of Suv Value in Pet-Ct with Tumor Differentiation and Tumor Markers in Gastric Cancer. Eurasian J Med 2019; 10.5152/eurasianjmed.2019.19016.

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