The Eurasian Journal of Medicine

An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response


Department of Physiology, Atatürk University Faculty of Medicine, Erzurum, Turkey


Department of Nutrition and Dietetics, Ağrı İbrahim Çeçen University Faculty of Medicine, Ağrı, Turkey


Department of Physiology, Yozgat Bozok University Faculty of Medicine, Yozgat, Turkey


Department of Physiology, Sakarya University Faculty of Medicine, Sakarya, Turkey


Department of Physiology, Yüksek İhtisas University Faculty of Medicine, Ankara, Turkey

Eurasian J Med 2022; 54: Supplement S62-S65
DOI: 10.5152/eurasianjmed.2022.22293
Read: 784 Downloads: 340 Published: 01 December 2022

Ischemia–reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia–reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia–reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia–reperfusion . There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1β, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa β, and LC3B (microtubu le-associated protein light chain 3, LC3) can be evaluated among these indicators.

Cite this article as: Can Güler M, Tanyeli A, Nur Ekinci Akdemir F, Eraslan E, Özbek Şebin S, Güzel Erdoğan D, Nacar T. An overview of ischemia– reperfusion injury: Review on oxidative stress and inflammatory response. Eurasian J Med., 2022;54(Suppl. 1), S62-S65

EISSN 1308-8742