The Eurasian Journal of Medicine
Review

Aquaporins: Potential Targets in Inflammatory Diseases

1.

Department of Pharmacology, Van Yüzüncü Yıl University Faculty of Pharmacy, Van, Turkey

2.

Department of Pharmacology, Atatürk University Hınıs Vocational College, Erzurum, Turkey

3.

Department of Pharmacology, Kafkas University Faculty of Medicine, Kars, Turkey

Eurasian J Med 2023; 55: Supplement 106-113
DOI: 10.5152/eurasianjmed.2023.23357
Read: 191 Downloads: 101 Published: 29 December 2023

Inflammation involves a long chain of molecular reactions and cellular activity designed to repair tissue damaged by various causes. The inflammatory process and its complex mechanisms have recently become a focus of interest for many researchers. After the onset of inflammation, various adverse conditions that initiate the inflammatory response need to be addressed; however, failure to limit the inflammatory reaction may result in the damage or destruction of host cells. Therefore, inflammatory reactions play a role in many diferent diseases. Aquaporins (AQPs), commonly referred to as water channels, are protein channels responsible for forming pores in the membranes of biological cells. Their main function is to aid in the movement of water between cells. Aquaporins not only regulate transepithelial fluid transport across membranes but also play a role in regulating essential events crucial for the inflammatory response. Aquaporins have been shown in many studies to have important roles in inflammatory diseases. This clearly indicates that AQPs may be potential targets for inflammatory diseases. This review summarizes the research to date on the structure and function of AQPs and provides an update on the relationship between AQPs and various human inflammatory diseases

Cite this article as: Bozkurt A, Halici H, Yayla M. Aquaporins: potential targets in inflammatory diseases. Eurasian J Med., 2023;55(Suppl. Issue: 1): S106-S113.

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