The Eurasian Journal of Medicine
Original Article

Clinical and Laboratory Findings by Serum Vitamin D Levels in Children with COVID-19

1.

Department of Pediatric Endocrinology, Erzurum Regional Training & Research Hospital, Erzurum, Turkey

2.

Department of Pediatric Endocrinology, Atatürk University Faculty of Medicine, Erzurum, Turkey

3.

Clinical Research Development and Design Application and Research Center, Atatürk University, Erzurum, Turkey

4.

Department of Pediatric Infectious Diseases, Erzurum Regional Training & Research Hospital, Erzurum, Turkey

5.

Department of Biochemistry, Erzurum Regional Training & Research Hospital, Erzurum, Turkey

6.

Department of Medical Microbiology, Erzurum Regional Training & Research Hospital, Erzurum, Turkey

Eurasian J Med 2022; 54: 285-291
DOI: 10.5152/eurasianjmed.2022.22213
Keywords : COVID-19, vitamin D, children
Read: 195 Downloads: 71 Published: 20 October 2022

Objective: The studies on children with COVID-19 are very limited. The aim of this study is to reveal the effect of serum 25-hydroxy vitamin D level on clinical and laboratory parameters.

Materials and Methods: The study included 74 children (35 boys and 39 girls) diagnosed with COVID-19. The retrospective data were obtained from the file records of the patients. Seventy-four patients were divided into 3 groups (group 1, deficient; group 2, insufficient; and group 3, sufficient) according to their serum 25-hydroxy vitamin D levels.

Results: The mean age of all patients was 113.25 ± 64.55 months. The mean leucocyte count was substantially higher in group 3 compared to groups 1 and 2 (P = .05 and P = .002, respectively). The mean lymphocyte and platelet count in group 3 was remarkably higher than both groups 1 and 2 (P = .001 and P = .002; and P = .04 and P = .01, respectively). The mean serum parathyroid hormone concentration in group 1 was markedly higher than both groups 2 and 3 (P=.003 and P = .002, respectively) while the mean serum 25-hydroxy vitamin D level in group 1 was remarkably lower than both groups 2 and 3 (P=.001 and P=.001, respectively). Serum 25-hydroxy vitamin D concentrations were positively correlated with leucocyte, lymphocyte, and platelet counts (r=0.221, P=.05; r=0.396, P=.001; and r=0.249, P=.03, respectively) while there was a negative correlation with parathyroid hormone concentrations (r=−0,436, P=.001).

Conclusion: This study suggests that COVID-19 has a benign course in children and that serum 25-hydroxy vitamin D concentration may have a role in the lymphocyte count.

Cite this article as: Ozden A, Doneray H, Hafize Erdeniz E, Altinkaynak K, Igan H. Clinical and Laboratory Findings by Serum Vitamin D Levels in Children with COVID-19. Eurasian J Med., 2022;54(3), 285-291.

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