Abstract

This study has been planned to elucidate the effect of uremia on human genome. For this purpouse, on the mitotic metaphases obtained from the cultured periferic blood samples of 18 patient with uremia to be given hemodialysis treatment for the first time and 15 healthy control subjects. Sister Chromatid Exchange (SCE) rates, numeric and structural chromosomal anomalies have been screened. SCE rate in patients with uremia was 9,48±0,29 per metaphase where it was observed as 6,51 ±0,24 per metaphases in healthy controls. Student-t test demonstrated that this difference was statistically significant (p=0.000). Standart cytogenetic analysis did not revealed any numeric or strucrural abnormalities in controls but in patient group some structural anomalies like chromosomal breaks, gaps, isogaps and acentric chromosomes were observed. These findings were supporting the idea that uremia may have some degrees of genotoxic effect.