The Eurasian Journal of Medicine
Original Article

Effects of Internal Exposure to 56MnO2 Powder on Blood Parameters in Rats


Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan


Semey Medical University, Semey, Kazakhstan


L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan


A.Tsyb Medical Radiological Research Center - National Medical Research Center of Radiology, Ministry of Health of Russian Federation, Obninsk, Russia


National Nuclear Center of the Republic of Kazakhstan, Kurchatov, Kazakhstan

Eurasian J Med 2020; 52: 52-56
DOI: 10.5152/eurasianjmed.2020.19228
Read: 1744 Downloads: 796 Published: 27 February 2020

Objective: The pathological effects of internal exposure to manganese dioxide-56 (56MnO2) radioisotope particles have been previously examined in rats. Here we further examine the effects of 56MnO2, focusing on changes in blood parameters.

Materials and Methods: Ten-week-old male Wistar rats were exposed to 3 doses of neutron-activated 56MnO2 powder, nonradioactive MnO2 powder, or external 60Co γ-rays (1 Gy, whole body). On days 3 and 61 postexposure, the animals were necropsied to measure organ weights and clinical blood parameters, including red blood cell and white blood cell counts; concentrations of calcium, phosphorus, potassium, and sodium; and levels of alanine aminotransferase (ALT), aspartate aminotransferase, amylase, creatinine, urea, total protein, albumin, triglycerides, high density lipoprotein, total cholesterol, and glucose.

Results: In the 56MnO2-exposed animals, accumulated doses were found to be highest in the gastrointestinal tract, followed by the skin and lungs, with whole-body doses ranging from 41 to 100 mGy. There were no 56MnO2 exposure-related changes in body weights or relative organ weights. The ALT level decreased on day 3 and then significantly increased on day 61 in the 56MnO2-exposed groups. There were no exposure-related changes in any other blood parameters.

Conclusion: Although the internal doses were less than 100 mGy, internal exposure of 56MnO2 powder showed significant biological impacts.

Cite this article as: Fujimoto N, Baurzhan A, Chaizhunusova N, et al. Effects of Internal Exposure to 56MnO2 Powder on Blood Parameters in Rats. Eurasian J Med 2020; 52(1): 52-6.

EISSN 1308-8742