Abstract

Behçet's disease is a chronic inflammatory multisystemic disorder of unknown cause, characterized by orogenital ulcers, uveitis, skin lesions, vascular, locomotor, pulmoner, gastrointestinal, and central nervous system manifestations. Behçet's disease clusters along the ancient ‘Silk Road' which extends from Eastern Asia to the Mediterranean. In recent years, higher Behçet's disease prevalence has been reported among Familial Mediterranean Fever (FMF) patients compared with general population. Mediterranaen Fever (MEFV) gene mutations in Behçet's disease was also reported to be more frequent.